DRUG KINETICS-PART-7-INTERMITTENT INTRAVENOUS INFUSIONS

INTERMITTENT I.V.INFUSIONS

In this post we deal with the action of body on the drug infused through the vein intermittently,in short periods to prevent the accumulation of the drug to produce toxicity.

Generally aminoglycosides such as gentamycin is infused for one hour in every 12 hours.In this course a steady state plasma concentration CSS  is not commonly reached.CSS is avoided to prevent drug accumulation to produce toxixity.

The peak plasma concentration is calculated as follows:-

                CPn    =R(1-e power -kt)(1-e power -nkt)/Cl(1-e power -kT)

Cpn is peak drug concentration,R-is the rate of drug infusion,Cl-is the total body clearance,T-is the dosage interval,and t-is the time duration of infusion.