AN EMINENT TRIAL TO CURE P.D.
Parkinson Disease is a devastating body condition that affects movements.The disease is progressive and brain wasting.The symptoms are tremors in the hands,limbs,jaws,and face;muscuar rigidity;impaired posture and gait.Speech problems also.
Depletion of an hormone called dopamine in P.D because there are unexplained damages of the dopamine cells in a part of the brain called substantia nigra.As the disease progresses the dopamine cells malfunctioning and die leading to insufficient secretion and circulation of dopamine.
Dopamine the hormone is functioning as a chemical messenger necessary for controlling movements.
Now a modern techniques of stem cell therapies for brain diseases such as P.D.is rapidly moving towards clinical trials.
However before the trial get ralized,it is very important to clear away the possiblities of consistantly produce high quality stem cells for transplant.
Now scientists in Sweden have foundout some insights plus a set of markers that should help control the quality of stem cells engineered for use in P.D.
The researches are conducted by the teams from the Lund University and the Karolinska Institute in Stockholm,Sweden.
Their work has been published in the journal Cell-Stem Cell.
In the study the researchers take a close look a the molecular pathways involved in the journey from a stem cells to a dopamine neuron.
In the other study they found out some important features of dopamine cell development and what make these cells different from other similar and neighbouring neuron.
The results should help fine-tune stem cell engineering to produce pure populations of high-quality dopamine neurons they said.
The main purpose of this study is to successfully a pool of progenitor cells into the brain of the patients so that they can make new supplies of dopamine cells,because he natural dopamine cell that dwindles during the progression of P.D.will not be able to regenerate or replaced by the body.
The teams in 2014,they showed how it is possible to produce dopamine cells from embryonic stem cells and transplant them into the brain of the rats that suffered from P.D. to replace the damaged cells.
In one of their papers they found out that it is not possible to just produce a population of active dopamin cells in a dish and induce hem into the brain.
They found that in case of brain disease like P.D.first of all they have implant immature stem cells to let them to differentiate and mature after planted into the brain which may take several months.
The declaration by the author Dr.Agnete Kirkeby,Lund University is as follows.
"We have identified a specific set of markers that correlate with high dopaminergic yield and graft function afer transplantation in animal models of P.D.
Guided by this study we have developed better and more accurate methods for producing dopamine cells for clinical use in a reproducible way"
No comments:
Post a Comment